بررسی اثرتجویز وریدی لیدوکائین بر درد و لرزش عضلانی ناشی از سوکسینیل کولین

Background and Objectives: Succinyl colin is a frequently used muscle relaxant in short duration and outpatient anesthesia. Muscular fasciculation and muscle pain (myalgia) are the two mild but frequent side effects of this medication. Respecting great discomfort of myalgia for the patients, the aim of this study was to measure the effect of intravenous lidocain injection on the myalgia and muscle fasciculation generated by succinyl coline. Materials and Methods: This is a clinical trial study which is performed on 100 patients who were candidates for elective short duration anesthesia requiring tracheal intubation. The patients were randomly divided into two groups of 50 patients. The treatment group received 1.5mg/kg intravenous lidocain and the control group received an equinoxes of distilled water intravenously before succinyl cholin injection. The frequency of myalgia and muscle fasciculation due to succinyl colin injection was compared between the two groups. Results: Results of this study showed that, in the treatment group 24 patients (48%) and in the control group 35 patients (70%) complained from myalgia. The difference was statistically significant (p<0.05). Incidence of fasciculation in lidocain group and control group was 34 (68%) and 50 (100%), respectively. The difference between these proportions was also statistically significant (p<0.05). Conclusion: Intravenous lidocain injection before succinyl colin reduced both fasciculation and muscle pain due to succinyl colin. Therefore, application of lidocain in short term and outpatient anesthesia could be recommended. Key words: Succinyl cholin, Myalgia, Fasciculation, Lidocain Funding: This research was funded by Rafsanjan University of Medical Sciences. Conflict of interest: None declared. Ethical approval: The Ethics Committee of the Rafsanjan University of Medical Sciences approved the study